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. 2018 May 10;2018(5):CD012069. doi: 10.1002/14651858.CD012069.pub2

Kim 2014a.

Methods A review of the medical records of children and adolescents receiving MPH for ADHD between 2004 and 2011
Participants Number of participants screened: not stated
Number of participants included: 157
Number of participants followed up: 157
Number of withdrawals: 0
Diagnosis of ADHD: DSM‐IV (subtype: combined (71.3%), hyperactive‐impulsive (0.6%), inattentive (28.0%))
Age: mean 8.9, range 5‐14 years old
IQ: 104.5 (SD 15.3), range 71‐143
Sex: 134 males, 23 females
Methylphenidate‐naïve: none
Ethnicity: not stated
Country: Korea
Comorbidity: ODD 30.6%, tic 17.8%, anxiety 11.5%, depressive disorder:4.5%, elimination disorder 2.5%
Comedication: not stated
Sociodemographics: not stated
Inclusion criteria
  1. Between 5 and 14 years at the start of treatment

  2. DSM‐IV diagnosis of ADHD

  3. Receiving methylphenidate for ≥ 1 year

  4. A baseline weight and height z score > −2.0 relative to the general Korean population


Exclusion criteria
  1. Prior exposure to a central nervous system stimulant or atomoxetine

  2. Having initiated MPH treatment before the age of 5 years

  3. IQ < 70 on the Korean Educational Developmental Institute's Wechsler Intelligence Scale for Children

  4. Past and/or current history of developmental disorder, including autism spectrum disorder

  5. Past and/or current history of schizophrenia, bipolar disorder, or other psychosis

  6. Current seizure disorder

  7. Mean compliance for the whole treatment period < 80%

  8. Taking an adjunct medication that could affect growth

  9. Past and/or current medical illness that could induce growth suppression

Interventions Methylphenidate type: OROS‐MPH 52.2%, ER‐MPH 26.1%, combination 27.1%
Mean methylphenidate dosage: 35.0 (SD 12.4 mg); 0.98 (SD 0.27) mg/kg/day
Administration schedule: not stated
Duration of intervention: ≥ 1 year; mean 28.8 months (SD 16.1); range 12‐88 months
Treatment compliance: ≥ 80%
Outcomes Non‐serious adverse events:
Weight and height Z score measured during the first and second year of MPH treatment
Notes Sample calculation: not stated
Ethics approval: not stated
Funding/vested interests: funded by the Korean Ministry of Education, Science and Technology
Key conclusions of the study authors: these results suggest that methylphenidate could be related to weight and height deficit in Korean children and adolescents, although the effects were minor, and disappeared after the 1st year
Exclusion of methylphenidate non‐responders/children who have previously experienced adverse events on methylphenidate: no