Lakic 2012.
Methods | A cohort study of the influence of methylphenidate treatment on the occurrence of tics and exacerbation of pre‐existing tics | |
Participants | Number of participants screened: not stated Number of participants included: 68 Diagnosis of ADHD: DSM‐TR‐IV (subtype: not stated) Age: range 7‐15 years old IQ: > 70 Sex: not stated Methylphenidate‐naïve: not stated Ethnicity: not stated Country: Serbia Comorbidity: tic disorder 9.7% Comedication: not stated Sociodemographics: not stated Inclusion criteria:
Exclusion criteria:
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Interventions | Methylphenidate type: sustained‐release Methylphenidate dose range: 18‐36 mg/day (individualised dose) Administration schedule: not stated Duration of intervention: > 6 weeks, up to 6 months Treatment compliance: not stated |
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Outcomes |
Non‐serious adverse events: Assessment of the occurrence of tics at the time of diagnosis, start of therapy and during methylphenidate treatment. Furthermore, monitoring (type, intensity, duration) of pre‐existing tics during methylphenidate treatment |
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Notes | Sample calculation: not stated Ethics approval: not stated Funding: no funding Authors' affiliations: not stated Key conclusions of the study authors: tics as a side effect of sustained‐release methylphenidate treatment in our patients was predominantly motor, of mild intensity and transient in nature, and did not require cessation of therapy Exclusion of methylphenidate non‐responders/children who have previously experienced adverse events on methylphenidate: not stated Supplemental outcome data and information about IQ and funding were received through personal email correspondence with the authors in October 2013 (Lakic 2013 [pers comm]) |