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. 2018 May 10;2018(5):CD012069. doi: 10.1002/14651858.CD012069.pub2

Lewis 2012.

Methods A patient report of a paediatric patient with glaucoma receiving methylphenidate treatment for 8 years
Participants Diagnosis of ADHD: DSM‐IV (subtype: combined)
Age: 10 years old
IQ: within normal limits
Sex: female
Country: USA
Comorbidity: primary open angle glaucoma. Physical examination within normal limits
Comedication: latanoprost 0.005% eye drops twice daily
Sociodemographics: not stated
Interventions Methylphenidate type: extended release
Methylphenidate dosage: 18 mg/day titrated to 54 mg/day over 6 months
Administration schedule: once daily
Duration of treatment: 8 years
Treatment compliance: not stated
Outcomes Non‐serious adverse events
No exacerbation of glaucoma:
Before methylphenidate treatment: after treatment for glaucoma, the patient's intraocular pressure was brought to a stable range between 16 mmHg and 19 mmHg in both eyes
During methylphenidate treatment: ophthalmic examination every 6 months showed intraocular pressure consistently in the 16‐19 mmHg range bilaterally
Notes Key conclusions of the study authors: this report concluded stimulant medication (methylphenidate) should not be withheld in patients with glaucoma as long as intraocular pressure (IOP) remains well controlled
Comments from the study authors: the actual risk associated with adrenergic medications in patients with open angle glaucoma is negligible, and there are no studies proving adverse effects on IOP in normal or open angle eyes
Supplemental information regarding IQ received through personal email correspondence with the authors in March 2014 (Lewis 2014 [pers comm])