Machado 2010.

Methods	A patient report of a 6‐year old girl developing acute choreoathetoid movements induced by methylphenidate treatment
Participants	Diagnosis of ADHD: DSM‐IV (subtype: not stated) Age: 6 years old IQ: above 70 Sex: female Ethnicity: not stated Country: USA Comorbidity: psychomotor developmental delay, discrete macrocephalus, congenital mild ataxia, and hyperactivity. Otherwise healthy Comedication: none Sociodemographics: her parents were first‐degree relatives. No family history of neurological disease
Interventions	Methylphenidate type: extended release Methylphenidate dosage: 18 mg/day Administration schedule: once daily in the morning Duration of treatment: single dose
Outcomes	Serious adverse events: After single dose extended‐release methylphenidate 18 mg: choreoathetoid movements of orofacial muscles, arms, and legs, with transient dystonic postures of the right arm
Notes	Key conclusions of the study authors: we believe that the immediate response ensuing chlorpromazine prescription argues in favor of a specific role for dopamine receptor antagonists in methylphenidate‐induced chorea Comments from the review authors: the author is not sure that the girl fulfilled criteria E of the ADHD diagnosis (DSM‐IV). The author only saw the girl once in the emergency unit Supplemental information regarding diagnosis and IQ received through personal email correspondence with the authors in October 2013 (Machado 2013 [pers comm])