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. 2018 May 10;2018(5):CD012069. doi: 10.1002/14651858.CD012069.pub2

Mohammadi 2009.

Methods 42 days double‐blind, parallel, randomised clinical trial with 2 arms:

  1. Ritalin

  2. Stimdate
Participants Number of participants screened: not stated
Number of participants included: 60
Number of participants randomised to Ritalin: 30; Stimdate: 30
Number of participants followed up in each arm: Ritalin: 24; Stimdate: 30
Number of withdrawals in each arm: Ritalin: 6; Stimdate: 0
Diagnosis of ADHD: DSM‐IV‐TR (subtype: not stated)
Age (Ritalin): mean 9.21 years (range 6‐15)
Age (Stimdate): mean 9.29 years (range 6‐15)
Sex (Ritalin): 23 males, 7 females
Sex (Stimdate): 22 males, 8 females
Methylphenidate‐naïve: not stated
Ethnicity: 100% Persian
Comorbidity: not stated
Comedication: not stated
IQ: > 70
Sociodemographics: not stated
Inclusion criteria

  1. ADHD DSM‐IV‐TR

  2. 6‐15 years old

  3. IQ > 70


Exclusion criteria

  1. Current diagnosis of any other axis I psychiatric disorders

  2. Substance abuse or dependency

  3. A history of seizures or any other serious medical disorders and use of any psychotropic drugs in the 6 weeks prior to the study
Interventions Participants were randomly assigned to Ritalin or Stimdate
Methylphenidate type: extended release (Ritalin) or Extended release (Stimdate)
Mean methylphenidate dosage: 25 mg/day. Titrated to the highest dose level; 1 mg/kg/day Ritalin or Stimdate, or a maximum of 40 mg/day
Administration schedule: orally twice daily 7.30‐8.00 am and 12:00 to 1:00 pm
Duration: 42 days
Treatment compliance: not stated
Outcomes No usable data
Notes Sample calculation: no
Ethics approval: not stated
Funding/vested interest: not stated
Key conclusions of the study authors: based on the results of this study, no significant difference was observed between the 2 medications, and it seems both drugs behave in a similar way. In addition, Stimdate appears to be effective and well tolerated for ADHD in children and adolescents in Iran
Exclusion of methylphenidate non‐responders/children who have previously experienced adverse events on methylphenidate: no
Supplemental data regarding side effects requested from the study authors twice in November 2013 with no reply