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. 2018 May 10;2018(5):CD012069. doi: 10.1002/14651858.CD012069.pub2

Moungnoi 2011.

Methods A retrospective, descriptive cohort study of methylphenidate use for long‐term administration and its impact on growth at 6 months, 1 years, 2 years, 3 years, 4 years, and 5 years' follow‐up
Participants Number of participants screened: not stated
Number of participants included: 96
Number of participants followed up: 6 participants followed up to 5 years
Number of withdrawals: more than 50% by 3rd year of follow‐up
Diagnosis of ADHD: DSM‐IV (subtype: combined, 100%)
Age: mean 8.62 years old (SD 1.70)
IQ: not stated
Sex: 75 males, 21 females
Methylphenidate‐naïve: not stated
Ethnicity: not stated
Country: Thailand
Comorbidity: not stated
Comedication: not stated, but children who received other medication continuing more than 3 months were excluded
Sociodemographics: not stated
Inclusion criteria:
  1. Age 6 years and above

  2. Start short‐acting methylphenidate medication at any time between 1 January 2000 to 31 31 December 2007

  3. Continued medicine ≥ 1 year


Exclusion criteria:
  1. ADHD children who received other medications continuing more than 3 months

  2. Concomitant genetic or neurological disorders

Interventions Methylphenidate type: short acting methylphenidate
Mean methylphenidate dosage: 6 months= 0.44 mg/kg/day, 1 year = 0.48 mg/kg/day, 2 years = 0.48 mg/kg/day, 3 years = 0.49 mg/kg/day, 4 years = 0.41 mg/kg/day and 5 years = 0.42mg/kg/day
Administration schedule: not stated
Duration of intervention: ≥ 1 year
Treatment compliance: not stated
Outcomes Non‐serious adverse events:
Height and weight, observer, beginning of short‐acting methylphenidate medication, 6 months, 1‐, 2‐, 3‐, 4‐, 5‐year follow‐up
Notes Sample calculation: yes. Margin of error 5%, estimated prevalence of ADHD 3.5‐5%, CI 95% = sample size 51‐73
Ethics approval: yes, Ethics Committee of the Queen Sirikit National Institute of Child Health
Funding/vested interests: none
Authors' affiliations: none
Key conclusions of the study authors: prolonged medication with short‐acting methylphenidate showed minimal impact on growth only at the first 6 months; however, growth could catch up in the adolescent period
Exclusion of methylphenidate non‐responders/children who have previously experienced adverse events on methylphenidate: not stated