Saieh 2004.

Methods	A patient report of hospitalisation due to hypertension during methylphenidate treatment
Participants	Diagnosis of ADHD: DSM‐IV (subtype: not stated) Age: 8 years old IQ: normal Sex: male Ethnicity: not stated Country: Chile Comorbidity: not stated Comedication: not stated Sociodemographics: maternal family history of hypertension
Interventions	Methylphenidate type: Ritalin Methylphenidate dosage: 0.32 mg/kg Administration schedule: not stated Duration of treatment: 6 months Treatment compliance: not stated
Outcomes	Serious adverse events: 72‐hour hospitalisation, emergency unit: Abdominal pain for 4 days prior to hospitalisation, intermittent accentuation (hours), no other symptoms Secondary hypertension: persistent hypertension (158/88 ‐ 170/105, pulse: 78‐98 bpm). Normal physical examination. Normal eye fundus and normal cardiological examination. Discontinuation of methylphenidate: hypertensive treatment only necessary for 24 hours. Normal blood pressure after 1 week
Notes	Key conclusions of the study authors: we want to draw attention to our experience of a patient who had hypertension, which was clearly related to the administration of MPH, and which disappeared when MPH was discontinued Comments from the study authors: unfortunately, only a few relevant publications and no national studies on the subject exist, so we do not know exactly the extent of this problem, although from anecdotal experience of verbal communication the incidence of tachycardia and hypertension appear to be low. Prospective studies should be performed to find the true incidence of complications with the use of methylphenidate and thus further establish careful and appropriate control of MPH‐treated patients to avoid these complications Funding/vested interest/authors affiliations: no affiliations to pharmaceutical companies stated Supplemental information regarding ADHD diagnostic criteria, IQ, type and dose of MPH, and duration of hospitalisation received through personal email correspondence with the authors in October and December 2013 (Saieh 2013 [pers comm])