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. 2018 May 10;2018(5):CD012069. doi: 10.1002/14651858.CD012069.pub2

Schertz 1996.

Methods A retrospective study examining predictors of weight loss in children with ADHD treated with methylphenidate or dextroamphetamine sulfate
Participants Number of participants screened: not stated
Number of participants included: 60 (total)
Number of participants included in methylphenidate group: 32
Number followed up: 60
Number of withdrawals: 0
Diagnosis of ADHD: DSM‐III‐R (subtype: not stated)
Age: mean 7.5 years old (range: 3.6‐15.5)
IQ: no mental retardation
Sex: 29 males, 3 females
Methylphenidate‐naïve: 0
Ethnicity: white 77%, African American 10%, Asian: 3%, Hispanic: 10%
Country: USA
Comorbidity: not stated
Comedication: not stated
Sociodemographics: not stated
Inclusion criteria:
  1. DSM‐III‐R diagnosis of ADHD

  2. ≥ 5 months treatment with methylphenidate in the Developmental and Behavioral Pediatrics of the Schneider Children's Hospital


Exclusion criteria:
  1. Prior trial of methylphenidate stimulant medication

  2. Concurrently taking a medication that can affect weight (e.g. clonidine)

  3. Having a major developmental disability (e.g. mental retardation, cerebral palsy or autism)

  4. If complete information was not available in the chart

Interventions Methylphenidate type: not stated
Mean methylphenidate dosage: 25.5 mg or 1 mg/kg/day
Administration schedule: not stated
Duration of intervention: mean duration 11.2 months (range 6‐20 months)
Treatment compliance: not assessed
Outcomes Weight and body mass index (BMI) were the 2 measures of adiposity used. Weight was expressed in terms of z scores derived from US normative data
Notes Sample calculation: no
Ethics approval: not stated
Funding: not stated
Vested interests/authors' affiliations: not stated
Key conclusions of the study authors: pretreatment weight, adjusted for age, gender and height is a significant predictor of weight loss in children with ADHD treated with either methylphenidate or dextroamphetamine sulphate. In contrast, pretreatment age, duration of treatment, and weight‐adjusted dose were not found to be significant predictors
Exclusion of methylphenidate non‐responders/children who have previously experienced adverse events on methylphenidate: not stated
Supplemental information regarding height and weight for the methylphenidate group requested from the authors by email correspondence in January 2014. No reply