Gastrointestinal system
Study	Symptom	Adverse events/total number of participants
Abdominal pain
Abbasi 2011	Abdominal pain	8/20
Akhondzadeh 2003	Abdominal pain	3/10
Akhondzadeh 2004	Abdominal pain	4/20
Amiri 2008	Abdominal pain	7/27
Ardic 2014	Stomach ache	16/101
Arnold 2004	Abdominal pain	15/89
Arnold 2010	Abdominal pain	7/150
Atzori 2009	Stomach pain	3/129
Barrickman 1995	Stomach ache	1/15
Berek 2011	Abdominal pain	12/762
Blader 2010	Abdominal pain	6/65
Chou 2012b	Abdominal pain	12/230
Cortese 2015	Abdominal pain	22/1426
Davari‐Ashtiani 2010	Abdominal pain	1/16
Dirksen 2002	Stomach ache	14/287
Dittmann 2014	Upper abdominal pain	4/195
Döpfner 2011a, OBSEER	Gastrointestinal pain	9/777
Döpfner 2011b	Gastrointestinal pain	6/113
Efron 1997	Stomach aches	40/123
El‐Fiky 2014	Stomach aches	9/31
Findling 2009	Abdominal pain	27/157
Garg 2014	Abdominal pain	3/27
Gau 2006	Stomach aches	8/32
Gerwe 2009	Abdominal pain	10/306
Golubchik 2011	Abdominal pain	1/9
Grcevich 2001	Stomach ache	2/75
Green 2011	Stomach aches	9/34
Greenhill 1983	Stomach aches	4/7
Gucuyener 2003	Stomach ache	14/119
Haertling 2015	Abdominal pain	4/239
Hammerness 2009	Stomach ache	2/57
Hazell 2003	Stomach pain	6/10
Işeri 2007	Abdominal pain	3/20
Jafarinia 2012	Abdominal pain	6/20
Kemner 2005 (FOCUS)	Abdominal pain	33/850
Khajehpiri 2014	Abdominal pain	9/71
Kim 2010	Abdominal pain	1/27
Kordon 2011	Abdominal pain	11/541
Kratochvil 2002	Abdominal pain	7/25
Lee 2007	Abdominal pain	6/110
Li 2011	Abdominal pain	12/34
Lyon 2010	Stomach discomfort	2/10
Maayan 2009	Gastrointestinal pain	2/8
Maia 2008	Stomach ache	2/31
McCracken 2016	Abdominal pain	28/61
Mohammadi 2004	Abdominal pain	0/11
Mohammadi 2010	Abdominal pain	8/19
Mohammadi 2012a	Stomach ache	5/23
Mohammadi 2012b	Abdominal pain	5/20
Na 2013	Stomach ache (abdominal pain)	19/103
Perera 2010	Abdominal pain	15/102
Peyre 2012a	Abdominal pain	7/121
Pierce 2010	Abdominal pain	3/71
Remschmidt 2005	Abdominal pain	3/89
Sahin 2014	Abdominal pain	7/30
Sangal 2006	Abdominal pain	4/79
Schulz 2010	Abdominal pain	9/145
Shang 2015	Abdominal pain	4/66
Silva 2004	Stomach ache	3/22
Song 2012	Abdominal pain	20/116
Steele 2006	Abdominal pain	10/72
Su 2015	Abdominal pain	10/205
Tasdelen 2015	Abdominal pain	4/17
Thorell 2009	Stomach aches	2/79
Valdizán Usón 2004	Abdominal pain	1/155
Wang 2007	Abdominal pain	15/166
Warshaw 2010	Abdominal pain	9/260
Weiss 2007	Abdominal pain	5/79
Wigal 2013	Abdominal pain	17/39
Wigal 2015	Abdominal pain	29/200
Wilens 2005	Abdominal pain	45/229
Wilens 2006	Abdominal pain	9/220
Wilens 2008	Abdominal pain	15/127
Yildiz 2010	Stomach ache	6/47
Yildiz 2011	Abdominal pain	3/11
Zarinara 2010	Abdominal pain	3/18
Zelnik 2015	Abdominal pain	36/128
Zheng 2011	Stomach ache	140/1154
Çetin 2015	Stomach ache	3/61
Constipation
Ardic 2014	Constipation	10/101
Khajehpiri 2014	Constipation	4/71
Mohammadi 2004	Constipation	2/11
Shang 2015	Constipation	1/66
Decreased appetite
Abbas 2006	Loss of appetite	2/90
Abbasi 2011	Loss of appetite	12/20
Akhondzadeh 2003	Decreased appetite	5/10
Akhondzadeh 2004	Decreased appetite	8/20
Altin 2013	Decreased appetite	27/221
Amiri 2008	Decreased appetite	26/27
Ardic 2014	Decreased appetite	47/101
Arnold 2010	Loss of appetite	11/150
Atzori 2009	Decreased appetite	27/129
Blader 2010	Decreased appetite	13/65
Chazan 2011	Decreased appetite	118/205
Chou 2012b	Decreased appetite	95/230
Cortese 2015	Decreased appetite	213/1426
Coşkun 2010	Decreased appetite	3/7
Davari‐Ashtiani 2010	Loss of appetite	11/16
Dirksen 2002	Decreased appetite	8/287
Dittmann 2014	Lack of appetite	5/195
Döpfner 2011a, OBSEER	Decreased appetite	8/777
Döpfner 2011b	Decreased appetite	3/113
Efron 1997	Poor appetite	69/123
El‐Fiky 2014	Decreased appetite	12/31
Famularo 1987	Decreased appetite	1/10
Findling 2009	Loss of appetite	81/157
Garg 2014	Decreased appetite	14/27
Gau 2006	Decreased appetite	19/32
Gau 2008	Loss of appetite	128/607
Germinario 2013	Decreased appetite	5/9
Gerwe 2009	Loss of appetite	83/263
Ghanizadeh 2013	Decreased appetite	1/26
Golubchik 2011	Decrease in appetite	4/9
Grcevich 2001	Appetite suppression	5/75
Green 2011	Poor appetite	13/14
Gucuyener 2003	Loss of appetite	23/119
Hammerness 2009	Decreased appetite	19/57
Hazell 2003	Appetite suppression	7/10
Hulvershorn 2012	Decreased appetite	6/25
Işeri 2007	Loss of appetite	3/20
Jafarinia 2012	Decreased appetite	11/20
Johnson 2013	Reduced appetite	26/45
Jung 2007	Appetite loss	16/83
Kemner 2005 (FOCUS)	Decreased appetite	49/850
Kim 2010	Decreased appetite	9/27
Kim 2011	Poor appetite	22/97
Kratochvil 2002	Anorexia	6/25
Lakic 2012	Loss of appetite	68/68
Lee 2007	Decreased appetite	31/110
Li 2011	Decreased appetite	13/34
Maayan 2009	Decreased appetite	7/11
Maia 2008	Barkley decreased appetite	19/31
Mayes 1994	Decreased appetite	14/63
McCracken 2016	Decreased appetite	31/61
Miller‐Horn 2008	Decreased appetite	2/23
Mohammadi 2004	Loss of appetite	4/11
Mohammadi 2010	Decreased appetite	17/19
Mohammadi 2012a	Loss of appetite	11/23
Mohammadi 2012b	Decreased appetite	9/20
Na 2013	Decreased appetite	66/103
Perera 2010	Loss of appetite	51/102
Peyre 2012a	Reduced appetite	9/121
Pierce 2010	Decreased appetite	7/71
Poulton 2003	Decreased appetite	12/13
Sahin 2014	Loss of appetite	21/30
Sangal 2006	Decreased appetite	19/79
Shang 2015	Decreased appetite	36/66
Silva 2004	Decreased appetite	7/22
Steele 2006	Decreased appetite	17/60
Su 2015	Decreased appetite	72/205
Tasdelen 2015	Loss of appetite	9/17
Thorell 2009	Loss of appetite	21/79
Valdizán Usón 2004	Loss of appetite	9/155
Valdizán Usón 2013	Appetite and nutrition disorders	68/689
Wang 2007	Decreased appetite	32/166
Warshaw 2010	Decreased appetite	77/260
Wigal 2013	Decreased appetite	21/39
Wigal 2015	Decreased appetite	38/200
Wilens 2005	Appetite suppression	55/229
Wilens 2008	Decreased appetite	35/127
Yalcin 2014	Decreased appetite	28/40
Yatsuga 2014	Decreased appetite	3/50
Yildiz 2010	Loss of appetite	27/47
Zarinara 2010	Decreased appetite	7/18
Zeni 2007	Decreased appetite	53/106
Zheng 2011	Loss of appetite	552/1154
Zheng 2015	Loss of appetite	16/123
Decreased weight
Abbas 2006	Weight loss	2/90
Abbasi 2011	Weight loss	6/20
Amiri 2008	Weight loss	7/27
Ardic 2014	Weight loss	25/101
Arnold 2004	Weight loss	3/76
Arnold 2010	Decreased weight	5/171
Berek 2011	Weight decrease	10/762
Cortese 2015	Weight loss	37/1426
Davari‐Ashtiani 2010	Weight loss	4/16
Dittmann 2014	Weight decrease	3/195
Döpfner 2011b	Weight loss	0/113
Findling 2009	Decreased weight	33/157
Grcevich 2001	Weight loss	3/75
Haertling 2015	Weight decreased	3/239
Işeri 2007	Weight loss	2/20
Johnson 2013	Weight loss	9/45
Kordon 2011	Weight decrease	8/541
Kratochvil 2002	Weight loss	2/25
Lakic 2012	Moderate loss of body weight	68/68
Mohammadi 2012a	Weight loss	9/23
Remschmidt 2005	Weight decrease	1/105
Sahin 2014	Weight loss	20/30
Song 2012	Weight loss	4/116
Warshaw 2010	Decreased weight	9/260
Wilens 2005	Weight loss	8/407
Yildiz 2010	Weight loss	12/47
Yildiz 2011	Weight loss	5/11
Çetin 2015	Weight loss	1/16
Diarrhoea
Abbasi 2011	Diarrhoea	5/20
Blader 2010	Diarrhoea	2/65
Hammerness 2009	Diarrhoea	3/57
Khajehpiri 2014	Diarrhoea	3/71
Kordon 2011	Diarrhoea	7/541
Kratochvil 2002	Diarrhoea	1/25
Mohammadi 2004	Diarrhoea	0/11
Mohammadi 2010	Diarrhoea	1/19
Dry mouth
Abbasi 2011	Dry mouth	8/20
Amiri 2008	Dry mouth	10/27
Blader 2010	Dry mouth	2/65
Davari‐Ashtiani 2010	Dry mouth	0/16
Işeri 2007	Dry mouth	1/20
Mohammadi 2004	Dry mouth	3/11
Mohammadi 2010	Dry mouth	6/19
Mohammadi 2012a	Dry mouth	3/23
Mohammadi 2012b	Dry mouth	3/20
Gastrointestinal adverse events
Dittmann 2014	Gastrointestinal disorders	6/247
Gau 2008	Gastrointestinal upset	36/607
Valdizán Usón 2013	Gastrointestinal symptomatology	9/633
Nausea
Abbasi 2011	Nausea	5/20
Akhondzadeh 2003	Nausea	2/14
Akhondzadeh 2004	Nausea	3/20
Amiri 2008	Nausea	4/27
Ardic 2014	Nausea	14/101
Arnold 2004	Nausea	7/76
Barrickman 1995	Nausea	1/18
Chou 2012b	Nausea	15/230
Dittmann 2014	Nausea	2/195
Döpfner 2011a, OBSEER	Nausea	9/777
Döpfner 2011b	Nausea	1/113
Findling 2009	Nausea	20/157
Garg 2014	Nausea	1/27
Ghanizadeh 2013	Nausea + vomiting	1/26
Gucuyener 2003	Nausea	11/119
Guerreiro 1996	Nausea	1/22
Haertling 2015	Nausea	4/239
Hammerness 2009	Nausea	4/57
Işeri 2007	Nausea	1/20
Kemner 2005 (FOCUS)	Nausea	9/850
Khajehpiri 2014	Nausea	4/71
Kim 2010	Nausea	1/27
Kordon 2011	Nausea	10/541
Kratochvil 2002	Vomiting + nausea + dyspepsia	4/25
Lee 2007	Nausea	5/110
Lee 2014	Nausea	5/100
Li 2011	Nausea	16/34
Mohammadi 2004	Nausea	0/11
Mohammadi 2010	Nausea	4/19
Na 2013	Nausea	32/103
Pierce 2010	Nausea	3/71
Schulz 2010	Nausea	8/145
Song 2012	Nausea	9/116
Su 2015	Nausea	11/205
Tasdelen 2015	Nausea	1/17
Wang 2007	Nausea	17/166
Warshaw 2010	Nausea	13/260
Wilens 2005	Nausea	7/407
Yildiz 2010	Nausea	9/47
Yildiz 2011	Nausea	5/11
Zarinara 2010	Nausea	5/18
Upset stomach
Arnold 2004	Dyspepsia	6/89
Hulvershorn 2012	Upset stomach	4/25
Na 2013	Dyspepsia	13/103
Vomiting
Arnold 2004	Vomiting	3/76
Dittmann 2014	Vomiting	1/195
Findling 2009	Vomiting	23/157
Jafarinia 2012	Vomiting	3/20
Kemner 2005 (FOCUS)	Vomiting	11/850
Lee 2007	Vomiting	8/110
Lee 2014	Vomiting	5/100
Maayan 2009	Vomiting	1/8
Mohammadi 2010	Vomiting	2/19
Mohammadi 2012a	Vomiting	3/23
Mohammadi 2012b	Vomiting	2/20
Na 2013	Vomiting	7/103
Shang 2015	Vomiting	5/66
Silva 2004	Vomiting	6/22
Su 2015	Vomiting	9/205
Valdizán Usón 2004	Vomiting	2/155
Wang 2007	Vomiting	6/166
Wilens 2005	Vomiting	6/407
Yildiz 2011	Vomiting	1/11
Zarinara 2010	Vomiting	4/18
Dyspepsia
Arnold 2004	Dyspepsia	6/76
Cortese 2015	Dyspepsia	9/1426
Gastroenteritis
Arnold 2004	Gastroenteritis	0/76
Wigal 2015	Gastroenteritis	4/200
Increased appetite
Blader 2010	Increased appetite	1/65
Xerostomia
Khajehpiri 2014	Xerostomia	12/71