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. 2018 May 10;2018(5):CD012069. doi: 10.1002/14651858.CD012069.pub2

Strandell 2007.

Methods A series of spontaneously reported cases of suicidal and self‐damaging behaviour from VigiBase
Participants Number of cases reported: 116
Diagnostic criteria not stated, nor subtype
Age(range): 5‐17 years old
IQ: not stated
Sex: not stated
Ethnicity: not stated
Country: not stated
Comorbidity: 78 were depressed, otherwise not stated
Comedication: in 33 cases methylphenidate and atomoxetine were co‐reported. 17 depressed patients were on antidepressants, and 42 were on antidepressants (without depression) ‐ (not clear if they were on atomoxetine or methylphenidate)
Sociodemographics: not stated
Interventions Methylphenidate type: not stated
Methylphenidate dosage: not stated
Administration schedule: not stated
Duration of intervention: not stated
Treatment compliance: not stated
Outcomes Serious adverse events:
Depression suicidal
Intentional overdose
Intentional self‐injury
Non‐accidental injury
Suicidal tendency
Suicide
Suicide attempt
Thoughts of self‐harm
Notes Ethics approval: not stated
Funding/vested interest/authors' affiliations: not stated
Key conclusions of the study authors: the number of reports with suicidal behaviour in children and adolescents raises concern. The reports do not only imply possible suicidal behaviour: young patients actually commit suicide
Comments from the review authors: this case‐series is based on a database of spontaneously reported adverse events. Therefore, some of these cases might have been reported in other case‐reports
Supplemental information, specifically asking for full‐text article and additional information, requested through email correspondence with the authors in November 2013. No reply