Musculoskeletal system
Study	Symptom	Adverse events/total number of participants
Chest pain
Arnold 2004	Chest pain	0/76
Hammerness 2009	Chest pain	2/57
Shang 2015	Chest pain	1/66
Height
Jensen 1999 (MTA)	No difference	‐
Kim 2010	Increased from baseline	128.7 cm (SD = 9.10)
Mohammadi 2012a	Increased from baseline	133.8 cm (SD = 14.81)
Vincent 1990	No difference	158.7 cm (SD = 10.2)
Wiguna 2012	Increased from baseline	0.55 cm (SD = no information)
Yalcin 2014	Increased from baseline	134.6 cm (SD = 12.32)
Weight
Davari‐Ashtiani 2010	Increased from baseline	Weight gain in 1/16 participants
Germinario 2013	Increased from baseline	38.4 kg (SD = 11.3)
Kim 2010	No difference	28.5 kg (SD = 6.40)
Kratochvil 2002	No difference	40.7 kg (SD = 17.2)
Mohammadi 2012a	Increased from baseline	32.7 kg (SD = 14.7)
Vincent 1990	No difference	Observed weight: 47.9 kg (SD = 10.3) Expected weight: 48.1 kg (SD = 10.6)
Wiguna 2012	Decreased from baseline	36.2 kg (SD = 11.9)
Yalcin 2014	Increased from baseline	Weight gain in 15/33 participants
BMI
Gerwe 2009	No difference	Mean change from baseline: −0.3 kg/m2 (SD = 0.70)
Mohammadi 2012a	No difference	18.2 kg/m2 (SD = 4.74)
Yalcin 2014	No difference	Methylphenidate group: 18.1 kg/m2 (SD = 2.76) Untreated group: 17.8k kg/m2 (SD = 2.71)
Height z score
Bereket 2005	Decreased from baseline	‐
Germinario 2013	Decreased from baseline	Z score = 0.36 (SD = 1.21)
Moungnoi 2011	Decreased from baseline	Z score = 0.09 (SD = no information)
Poulton 2003	Decreased from baseline	Z score = 0.26 (SD = 0.82)
Poulton 2012	Decreased from baseline	Z score = 0.34 (SD = 0.81)
Schertz 1996	Decreased from baseline	Z score = ‐0.1(SD = no information)
Spencer 1992	Decreased from baseline	Z score = ‐0.23 (SD = 0.42)
Weight z score
Bereket 2005	Decreased from baseline	0.2 (SD = 1.04)
Gerwe 2009	Decreased from baseline	0.26 kg (SD = 1.40)
Moungnoi 2011	Decreased from baseline	Z score = 0.01 (SD = no information)
Poulton 2003	Decreased from baseline	Z score = 0.44 (SD = 0.97)
Schertz 1996	Decreased from baseline	‐
BMI z score
Bereket 2005	No difference	After 14 months: Age‐adjusted SD = 0.71 Sex‐adjusted SD = 0.65
Dubnov‐Raz 2011	No difference	‐
Poulton 2012	No difference	‐
Increased mobility
Ardic 2014	Increased mobility	22/122
Bone mineral density
Lahat 2000	Quote: "There was no significant difference between serum calcium, phosphorus or bone‐specific alkaline phosphatase, urinary deoxypyridinoline, or bone mineral density in the two groups of children. No child deviated from his height percentile during the treatment period."	NA