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. 2018 May 10;2018(5):CD012069. doi: 10.1002/14651858.CD012069.pub2

Tølløfsrud 2006.

Methods A patient report of death caused by heart failure (acute dilated cardiomyopathy) during methylphenidate treatment
Participants Diagnosis of ADHD: ICD‐10 (subtype: not stated)
Age: 17 years old
IQ: no intellectual disability
Sex: male
Ethnicity: not stated
Country: Norway
Comorbidity: Tourette's syndrome
Comedication: none
Sociodemographics: not stated
Interventions Methylphenidate type: not stated
Methylphenidate dosage: 15 mg
Administration schedule: 3 times daily
Duration of treatment: 10 years
Treatment compliance: not stated
Outcomes Serious adverse events:
 Heart failure resulting in death
Notes Key conclusions of the study authors: heart failure leading to death, possibly caused by methylphenidate treatment
Comments from the study authors: dilated cardiomyopathy can be a rare side effect of methylphenidate use
Funding/vested interest/authors' affiliations: none
 Supplemental information regarding ADHD diagnosis and IQ received through personal email correspondence with the authors in November 2013 (Tølløfsrud 2013 [pers comm])