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. 2018 May 10;2018(5):CD012069. doi: 10.1002/14651858.CD012069.pub2

Van der Oord 2007.

Methods A 4‐week pseudorandomised, placebo‐controlled, cross‐over study investigating the additional value of short‐term intensive multimodal behaviour therapy to optimally titrated methylphenidate
Follow‐up 4.5 to 7.5 years after treatment
Participants Number of participants screened: not stated
Number of participants included in methylphenidate group: 23; included in methylphenidate + multimodal behaviour therapy: 27
Number of participants followed up in methylphenidate group: 21
Number of withdrawals in methylphenidate group: 2
Diagnosis of ADHD: DSM‐IV/I (subtype: combined (n = 31), hyperactive‐impulsive (n = 3), inattentive (n = 16))
Age: mean 9.6 years old
IQ: 96.81
Sex: not stated
Methylphenidate‐naïve: 100%
Ethnicity: white: 89%, others: 11%
Country: Netherlands
Setting:
Comorbidity: oppositional defiant disorder/conduct disorder 61.9%, oppositional defiant disorder 46%, conduct disorder 4%
Comedication: no
Sociodemographics: most parents medium to high education level
Inclusion criteria:
  1. ADHD according to DSM‐IV

  2. Full scale IQ above 75 (WISC‐R)


Exclusion criteria:
  1. Inadequate mastering of Dutch language by the child or both parents

  2. A history of methylphenidate use

Interventions Methylphenidate type: not stated
Methylphenidate dosage: 5 mg, 10 mg, and 20 mg in titration period
Administration schedule: 7:30 am, 12:30 pm
Duration of intervention: 4 week pseudo randomised cross‐over design, 1 week medication‐free, 5 weeks optimal dose
Treatment compliance: high, weekly phone calls to parents and teachers
Outcomes The MTA Side Effect Rating Scale was used to assess side effects
Notes Sample calculation: yes (power calculation)
Ethics approval: not stated
Funding: not stated
Vested interest/authors' affiliations: not stated
Key conclusions of the study authors: no evidence was found for the additive effect of multimodal behaviour therapy next to optimally titrated methylphenidate
Exclusion of methylphenidate non‐responders/children who have previously experienced adverse events on methylphenidate: no
Supplemental information regarding data on adverse events received through personal email correspondence with the authors in January 2014 (Van der Oord 2014 [pers comm])