Van der Oord 2007.
Methods | A 4‐week pseudorandomised, placebo‐controlled, cross‐over study investigating the additional value of short‐term intensive multimodal behaviour therapy to optimally titrated methylphenidate Follow‐up 4.5 to 7.5 years after treatment |
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Participants | Number of participants screened: not stated Number of participants included in methylphenidate group: 23; included in methylphenidate + multimodal behaviour therapy: 27 Number of participants followed up in methylphenidate group: 21 Number of withdrawals in methylphenidate group: 2 Diagnosis of ADHD: DSM‐IV/I (subtype: combined (n = 31), hyperactive‐impulsive (n = 3), inattentive (n = 16)) Age: mean 9.6 years old IQ: 96.81 Sex: not stated Methylphenidate‐naïve: 100% Ethnicity: white: 89%, others: 11% Country: Netherlands Setting: Comorbidity: oppositional defiant disorder/conduct disorder 61.9%, oppositional defiant disorder 46%, conduct disorder 4% Comedication: no Sociodemographics: most parents medium to high education level Inclusion criteria:
Exclusion criteria:
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Interventions | Methylphenidate type: not stated Methylphenidate dosage: 5 mg, 10 mg, and 20 mg in titration period Administration schedule: 7:30 am, 12:30 pm Duration of intervention: 4 week pseudo randomised cross‐over design, 1 week medication‐free, 5 weeks optimal dose Treatment compliance: high, weekly phone calls to parents and teachers |
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Outcomes | The MTA Side Effect Rating Scale was used to assess side effects | |
Notes | Sample calculation: yes (power calculation) Ethics approval: not stated Funding: not stated Vested interest/authors' affiliations: not stated Key conclusions of the study authors: no evidence was found for the additive effect of multimodal behaviour therapy next to optimally titrated methylphenidate Exclusion of methylphenidate non‐responders/children who have previously experienced adverse events on methylphenidate: no Supplemental information regarding data on adverse events received through personal email correspondence with the authors in January 2014 (Van der Oord 2014 [pers comm]) |