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. 2018 May 10;2018(5):CD012069. doi: 10.1002/14651858.CD012069.pub2

Varley 2001.

Methods A retrospective chart review
Participants Number of participants screened: 555
Number of participants included: 517
Diagnosis of ADHD: DSM‐IV (subtype: not stated)
Age: mean 11 years old (range not stated)
IQ: not stated
Sex: not stated
Methylphenidate‐naïve: not stated
Ethnicity: not stated
Country: not stated
Comorbidity: tics
Comedication: no
Sociodemographics: not stated
Inclusion criteria:
  1. ADHD


Exclusion criteria:
  1. Comedication

Interventions Methylphenidate type: not stated
Mean methylphenidate dosage: not stated
Administration schedule: not stated
Duration of intervention: not stated
Treatment compliance: not stated
Outcomes Non‐serious adverse events
Retrospective review of medical records. It was recorded whether the participants did or did not have a reported history of tic emergence in the course of pharmacologic treatment in that clinic.
8.3% (31 of 374) of participants treated with methylphenidate developed tics
Notes Sample calculation: no
Ethics approval: not stated
Funding/vested interest: supported by a National Institutes of Health Biomedical Research Support Grant, 1991
Authors' affiliations: not stated
Key conclusions of the study authors: tics was not related to dose nor treatment length, and may not be related to stimulants
Exclusion of methylphenidate non‐responders/children who have previously experienced adverse events on methylphenidate: not stated
Supplemental information requested through personal email correspondence with the authors in April 2014. No reply