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. 2018 May 10;2018(5):CD012069. doi: 10.1002/14651858.CD012069.pub2

Yilmaz 2013.

Methods A patient report of methylphenidate‐induced acute orofacial and extremity limb dyskinesia
Participants Diagnosis of ADHD: DSM‐IV
Age: 7 years old
IQ: above 70
Sex: male
Ethnicity: Turkish
Country: Turkey
Comorbidity: epilepsy
Comedication: sodium valproate
Sociodemographics: not stated
Interventions Methylphenidate type: not stated
Methylphenidate dosage: 18 mg
Administration schedule: once daily in the morning
Duration of treatment: 1 dose
Treatment compliance: good
Outcomes Serious adverse events:
Involuntary movements started about 5 hours after taking methylphenidate. Lip‐licking, lip‐smacking and tongue‐rolling movements. Dyskinetic tongue movements inside and outside the mouth and involuntary bilateral arm swinging while sitting and standing. Opening and closing his fingers without complete extension. Occasional repetitive movements of the feet, such as beating them against each other while sitting. About 15 hours after methylphenidate intake both hand‐mouth movements and excessive mobility had significantly resolved. Dyskinetic symptoms had completely disappeared on the second day of hospitalisation, and the patient was discharged
Notes Funding/vested interest/authors' affiliations: authors declare that there are no potential conflicts of interest
Key conclusions of the study authors: this case is reported to emphasise the potential side effects of methylphenidate, individual differences in drug sensitivities, and drug‐receptor interactions via different mechanisms
Comments from the study authors: antiepileptic therapy may increase the sensitivity to the side effects of methylphenidate
Supplemental data received through personal email correspondence with the authors in December 2013 (Yilmaz 2013 [pers comm])