Central nervous system: other specific adverse events
Study
Anorexia
Findling 1996	A case report about an 11‐year‐old girl who experienced transient side effects after receiving methylphenidate: mild and transient anorexia, transient weight loss of 2 kg observed in the initiation of methylphenidate therapy
Obsessive compulsive disorder (OCD) symptoms
Coşkun 2011	A case report of OCD symptoms during methylphenidate treatment. Decreased appetite and initial headache with 18 mg/day of osmotic‐controlled release oral delivery system (OROS) methylphenidate, and obsessive‐compulsive symptoms, decreased appetite, facial grimace, and nail picking/biting with 27 mg/day of OROS methylphenidate. Gradual disappearance of symptoms, although still subsyndromal obsessive‐compulsive symptoms, with discontinuation of medication. Mild facial grimace and similar obsessive‐compulsive symptoms with re‐administration of 27 mg/day of OROS methylphenidate. After three weeks, total score of 21 on Children's Yale‐Brown Obsessive‐Compulsive Scale (CY‐BOCS)
Woolley 2003	Obsessions and compulsions with anxiety. DSM‐IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edtion) diagnosis of OCD. Washing hands excessively, which was accompanied by checking rituals, reassurance seeking, and emetophobia. When methylphenidate was withdrawn, OCD symptoms decreased rapidly but increased when methylphenidate was reintroduced
Headache
Mize 2004	A case report of headache and mild depression during methylphenidate treatment
EEG changes
Dupuy 2008	A controlled before‐and‐after study investigating the effects of stimulants on EEG (electroencephaolography) coherence in 9 girls with ADHD (attention deficit hyperactivity disorder); intrahemispheric and interhemispheric coherences in girls with ADHD who were treated with stimulant medication. Girls had elevated frontal coherence in all frequency bands