Other body systems
Study
Skin reactions
Cohen 1992	Case 1: 5 days of MPH treatment: hospitalisation due to two days of severe swelling and redness of the scrotum The skin eruption resolved spontaneously four days after MPH was discontinued. Two weeks later, 18 hour after MPH retrial, the same skin eruption of the scrotum was documented. Discontinued once again, and followed by a complete resolution of the rash in four days Case 2: 7 days of MPH treatment: Six hours of severe swelling and redness of the scrotum. Discontinuation of MPH was followed by a complete resolution of rash in three days.Rechallenge with MPH two months later was followed by the same skin eruption of the scrotum within two days. Complete resolution was seen after drug withdrawal
Coşkun 2009a	OROS‐MPH 18 mg/day, co‐medication: valproate 400 mg/day. Maculopapular pruritic skin eruptions on the patient's neck, arms, and legs, one week after starting OROS MPH treatment Re‐administering of OROS‐MPH 18 mg/day, comedication: gabapentine 300 mg/day. Same skin eruptions with same severity, nine days after starting OROS‐MPH treatment again Discontinuation of medication: skin lesions abated within the next several weeks Restart of IR‐MPH, 10–20 mg/day, co‐medication gabapentine 300 mg/day, four months: no skin eruptions
Problems with sedation
Ririe 1997	A case report (6‐year‐old boy) on unexpected interaction of methylphenidate (Ritalin) with anaesthetic agents: There could be a potential risk of unwanted interactions between methylphenidate and anaesthetic agents. Based on the observations from the case report, a more detailed and systematic investigation of methylphenidate in patients undergoing anaesthesia or sedation is warranted
Eye problems
Ghanizadeh 2008c	Photophobia, occurring a few days after initiation of MPH treatment Discontinuation of MPH at least three times: no symptoms of photophobia Re‐administration of MPH: immediate reoccurrence of photophobia
Lewis 2012	This report concluded stimulant medication (MPH) should not be withheld in patients with glaucoma as long as intraocular pressure (IOP) remains well controlled