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. 2018 May 10;2018(5):CD012069. doi: 10.1002/14651858.CD012069.pub2

Agarwal 2008.

Methods A patient report of the combination of atomoxetine and methylphenidate in the treatment of ADHD
Participants Diagnosis of ADHD: DSM‐III‐R/DSM‐I (subtype: combined)
Age: 8 years old
IQ: normal (attends school)
Sex: male
Methylphenidate naïve: no
Ethnicity: not stated
Country: India
Comorbidity: not stated
Comedication: not stated. No atomoxetine (in the period relevant for this review)
Sociodemographics: not stated
Interventions Immediate release methylphenidate gradually increased to 50 mg/day
Administration schedule: 3‐4 divided dosages
Duration of intervention: 6 months
Treatment compliance: not stated
Outcomes Non‐serious adverse events:
Decreased appetite and delayed sleep onset
Notes Key conclusions of the study authors: the combination of atomoxetine and methylphenidate may be used more often in patients who are not able to tolerate high doses of methylphenidate or develop tolerance to it