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. 2018 May 10;2018(5):CD012069. doi: 10.1002/14651858.CD012069.pub2

Bereket 2005.

Methods A longitudinally study of 16 months of methylphenidate treatment in newly diagnosed and untreated children
Participants Number of participants screened: not stated
Number of participants included: 72
Number of participants followed up: 14
Number of withdrawals: 58
Diagnosis of ADHD: DSM‐IV (subtypes: not stated)
Age: mean 8.12 years, range 6.47‐10.32
IQ: none with mental retardation
Sex: 10 males, 4 females
Methylphenidate‐naïve: 100%
Ethnicity: Turkish
Country: Turkey
Comorbidity: not stated
Comedication: not stated
Sociodemographics: not stated
Inclusion criteria:
  1. ADHD according to DSM‐IV, confirmed by 2 child psychiatrists


Exclusion criteria:
  1. Prematurity

  2. Low birth weight

  3. Any systemic disease

Interventions Methylphenidate type: not stated
Methylphenidate dosage: 0.75 mg/kg
Administration schedule: not stated
Duration of intervention: 16 months
Treatment compliance: not stated
Outcomes Non‐serious adverse events:
Height measured with a Harpenden stadiometer. Performed every 4 months
Weight measured "with minimal clothing". Performed every 4 months
Height and weight measurements were transformed to SDs before the statistical analyses using normative data for Turkish children. BMI values were transformed to SDs according to data from Cole 2007
Notes Sample calculation: no
Ethics approval: approved by local ethics committee
Funding: supported by a TUBITAK grant
Vested interest/authors' affiliations: not stated
Key conclusions of the study authors: prepubertal children with ADHD had normal height, weight, BMI, serum IGF‐I and IGFBP‐3 and thyroid functions. Methylphenidate treatment had no sustained effects on growth parameters, IGF‐I and IGFBP‐3 during the follow‐up period of this study. However, it caused a mild decrease in total and free T4, which may warrant further monitoring
Supplemental information received through personal email correspondence with the authors in January 2014 (Bereket 2014 [pers comm])