Cohen 1992.

Methods	2 patient reports on fixed drug eruption of the scrotum due to methylphenidate treatment
Participants	Number of participants: 2 Diagnosis of ADD: DSM Age: 8 and 10 years old IQ: > 80 Sex: male Ethnicity: unknown Country: Israel Comorbidity: unknown Comedication: none Sociodemographics: unknown
Interventions	Methylphenidate type: not stated Methylphenidate dosage: 10 mg Administration schedule: once daily Duration of intervention: case 1: 5 days. Case 2: 7 days Treatment compliance: unknown
Outcomes	Non‐serious adverse effects: Fixed drug eruption (FXD) (a term used to describe a sharply localised dermatitis that characteristically recurs at the same site each time the offending drug is administered) Case 1 5 days of methylphenidate treatment: hospitalisation due to 2 days of severe swelling and redness of the scrotum. The skin eruption resolved spontaneously 4 days after methylphenidate was discontinued. 2 weeks later, 18 hour after methylphenidate retrial, the same skin eruption of the scrotum was documented. Discontinued once again, and followed by a complete resolution of the rash after 4 days Case 2 7 days of methylphenidate treatment: 6 hours of severe swelling and redness of the scrotum. Discontinuation of methylphenidate was followed by a complete resolution of rash after 3 days. Re‐challenge with methylphenidate 2 months later was followed by the same skin eruption of the scrotum within 2 days. Complete resolution was seen after drug withdrawal
Notes	Key conclusions of the study authors: fixed drug rash induced by methylphenidate is a possible but rare phenomenon. Because this drug is prescribed so often, it is important for physicians to be familiar with this phenomenon Supplemental information regarding ADHD diagnosis and IQ received through personal email correspondence with first author in July 2013 (Cohen 2013 [pers comm])