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. 2018 May 10;2018(5):CD012069. doi: 10.1002/14651858.CD012069.pub2

Coşkun 2008.

Methods A patient report of tactile and visual hallucinations with the combination of OROS methylphenidate and fluoxetine
Participants Diagnosis of ADHD: DSM‐IV (subtype: combined)
Age: 10 years old
IQ: intellectual capacity within normal range
Sex: male
Ethnicity: Turkish
Country: Turkey
Comorbidity: oppositional defiant disorder, generalised and separation anxiety disorders
Comedication: fluoxetine 10 mg/day
MPH‐naïve: yes
Sociodemographics: not stated
Interventions OROS MPH 18 mg/day, comedication: fluoxetine, 10 mg/day
OROS MPH 18 mg/day monotherapy, 2 weeks
Treatment compliance: not stated
Outcomes Non‐serious adverse events:
Tactile and visual hallucinations. Worsening of previous sleep disturbance and decreased appetite
Notes Funding/vested interests: the authors have no conflict of interest with any commercial or other associations, and no financial ties to disclose in connection with the submitted article
Key conclusions of the study authors: here we report a paediatric patient who developed tactile and visual hallucinations with the combination of OROS methylphenidate and fluoxetine
Comments from the study authors: in conclusion, we think that the causative agent was the combination of both medications rather than either medication alone. However, in either situation, it is important to note that this distressing side effect may occur even in the absence of underlying psychotic or substance‐related disorders, and clinicians' awareness is important in this issue, particularly in cases where polypharmacy is considered
Supplemental information regarding ADHD diagnostic criteria, subtype of ADHD and ethnicity received through personal email correspondence with the authors in August 2013 (Coşkun 2013 [pers comm])