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. 2018 May 10;2018(5):CD012069. doi: 10.1002/14651858.CD012069.pub2

Coşkun 2011.

Methods A patient report of obsessive‐compulsive symptoms during methylphenidate treatment
Participants Diagnosis of ADHD: unknown (subtype: combined)
Age: 10 years old
IQ: normal
Sex: female
Ethnicity: Turkish
Country: Turkey
Comorbidity: subsyndromal social and generalised anxiety disorders
Comedication: unknown
Sociodemographics: unknown
Interventions Osmotic release oral system methylphenidate, 18 mg/day, 1 year
Treatment compliance: unknown
Osmotic release oral system methylphenidate, 27 mg/day, 3 + 3 weeks
Treatment compliance: unknown
Outcomes Non‐serious adverse events:
Osmotic release oral system methylphenidate, 18 mg/day: decreased appetite and initial headache
Osmotic release oral system methylphenidate, 27 mg/day: obsessive‐compulsive symptoms, decreased appetite, facial grimace, nail picking/biting
Discontinuation of medication: gradually disappearance of symptoms, still subsyndromal obsessive‐compulsive symptoms
Re‐administering of osmotic release oral system methylphenidate, 27 mg/day: mild facial grimace, similar obsessive‐compulsive symptoms. After 3 weeks: Children's Yale‐Brown Obsessive‐Compulsive Scale (CY‐BOCS), total score = 21
Notes Key conclusions of the study authors: clinicians treating children should be familiar with the emergence and management of these unusual side effects
Supplemental information was received through personal email correspondence with the authors in August 2013 (Coşkun 2013d [pers comm])