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. 2018 Apr 4;2018(4):CD012256. doi: 10.1002/14651858.CD012256.pub2

Summary of findings 2. Complete dentures: same technique, different final‐impression materials.

Wax versus polysulfide rubber for making dentures for completely edentulous people
Population: completely edentulous people
Setting: university dental clinic
 Intervention: wax
 Comparison: polysulfide rubber
Outcomes Anticipated absolute effects* (95% CI) Relative effect
 (95% CI) Number of participants
 (studies) Quality of the evidence
 (GRADE) Comments
Risk with rubber Risk with wax
Participant‐reported oral health‐related quality of life (OHIP‐EDENT) Not measured
Participant‐reported quality of the denture Not measured
Number of border adjustments and sore spots after insertion of denture
Follow‐up: one year
571 per 1000 463 per 1000
 (217 to 971) RR 0.81
 (0.38 to 1.70) 27
 (1 RCT) ⊕⊝⊝⊝
 very low1 2 3  
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
 CI: confidence interval; RR: risk ratio; OR: odds ratio
GRADE Working Group grades of evidenceHigh quality: We are very confident that the true effect lies close to that of the estimate of the effect
 Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
 Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect
 Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect

1 Downgraded for risk of bias due to the single study contributing data for this outcome being at unclear risk of bias in many domains

2 Downgraded for imprecision due to the wide 95% CI starting from 0.38 highly beneficial to 1.70 no benefit.

3 Downgraded for indirectness due to the single study with only 27 participants. Hence generalisation becomes difficult.