Comparison 2. Processed EEG versus clinical signs guided anaesthesia (sensitivity analysis).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 POD	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 The best‐case scenario	3	2338	Risk Ratio (M‐H, Random, 95% CI)	0.69 [0.58, 0.83]
1.2 The worst‐case scenario	3	2338	Risk Ratio (M‐H, Random, 95% CI)	0.73 [0.61, 0.87]
2 POCD at one week	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 The best‐case scenario	3	2270	Risk Ratio (M‐H, Random, 95% CI)	0.77 [0.55, 1.09]
2.2 The worst‐case scenario	3	2270	Risk Ratio (M‐H, Random, 95% CI)	0.89 [0.71, 1.11]
3 POCD at 12 weeks	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 The best‐case scenario	3	2270	Risk Ratio (M‐H, Fixed, 95% CI)	0.67 [0.50, 0.89]
3.2 The worst‐case scenario	3	2270	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.57, 1.00]