Comparison 2. Antifibrinolytic drugs vs placebo or open control.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Death or dependence (mRS 4 to 6) at day 90	1	24	Risk Ratio (IV, Random, 95% CI)	1.25 [0.57, 2.75]
1.1 Acute spontaneous ICH	1	24	Risk Ratio (IV, Random, 95% CI)	1.25 [0.57, 2.75]
2 Death by day 90	3	57	Risk Ratio (IV, Random, 95% CI)	1.16 [0.31, 4.39]
2.1 Acute spontaneous ICH	3	57	Risk Ratio (IV, Random, 95% CI)	1.16 [0.31, 4.39]
3 All serious adverse events	1	24	Risk Ratio (IV, Random, 95% CI)	1.5 [0.39, 5.83]
3.1 Acute spontaneous ICH	1	24	Risk Ratio (IV, Random, 95% CI)	1.5 [0.39, 5.83]
4 Thromboembolic serious adverse events	1	24	Risk Ratio (IV, Random, 95% CI)	1.59 [0.07, 35.15]
4.1 Acute spontaneous ICH	1	24	Risk Ratio (IV, Random, 95% CI)	1.59 [0.07, 35.15]
5 Barthel Index	1	24	Mean Difference (IV, Random, 95% CI)	‐22.50 [‐45.65, 0.65]
5.1 Acute spontaneous ICH	1	24	Mean Difference (IV, Random, 95% CI)	‐22.50 [‐45.65, 0.65]
6 EuroQoL health utility score	1	24	Mean Difference (IV, Random, 95% CI)	‐0.04 [‐0.35, 0.27]
6.1 Acute spontaneous ICH	1	24	Mean Difference (IV, Random, 95% CI)	‐0.04 [‐0.35, 0.27]
7 Intracerebral haemorrhage growth by 24 hours	3	57	Risk Ratio (IV, Random, 95% CI)	0.76 [0.56, 1.05]
7.1 Acute spontaneous ICH	3	57	Risk Ratio (IV, Random, 95% CI)	0.76 [0.56, 1.05]