Liu 2012

Methods	Randomized controlled trial with parallel groups 1 centre
Participants	Adults (n = 26) with ARDS and sepsis, including septic shock (n = 12)
Interventions	Hydrocortisone (100 mg intravenous bolus 8‐hourly for 7 consecutive days) Placebo (normal saline)
Outcomes	PRIMARY Unclear SECONDARY 28‐Day mortality Prevalence of shock within 28 days SOFA score (information for SOFA score at day 7 not available) ICU length of stay Safety
Notes	Study location: China
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated randomization scheme
Allocation concealment (selection bias)	Unclear risk	No explicit information in the manuscript
Blinding (performance bias and detection bias) All outcomes	Unclear risk	No explicit information in the manuscript
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No explicit information in the manuscript
Selective reporting (reporting bias)	Unclear risk	No information
Other bias	Unclear risk	No information