Sabry 2011

Methods	Randomized controlled trial 3 centres
Participants	Adults (n = 80) admitted to ICU with community‐acquired pneumonia and sepsis
Interventions	Hydrocortisone (intravenous loading dose of 200 mg over 30 minutes, followed by 300 mg in 500 mL 0.9% saline at a rate of 12.5 mg/h) for 7 days Placebo (normal saline)
Outcomes	PRIMARY Improvement in PaO2:FiO2 (PaO2:FiO2 > 300 or ≥ 100 increase from study entry) SECONDARY SOFA score by day 8 Development of delayed septic shock ICU mortality rate
Notes	Study location: Egypt
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information in the manuscript
Allocation concealment (selection bias)	Unclear risk	No information in the manuscript
Blinding (performance bias and detection bias) All outcomes	Unclear risk	No information in the manuscript
Incomplete outcome data (attrition bias) All outcomes	Low risk	Lost to follow‐up: none
Selective reporting (reporting bias)	Unclear risk	No information in the manuscript
Other bias	Unclear risk	No information in the manuscript