Tandan 2005

Methods	Randomized controlled trial with 2 parallel groups 1 centre
Participants	Adults (n = 28) with septic shock and adrenal insufficiency
Interventions	Hydrocortisone (stated low dose but actual dose and duration not reported) Placebo
Outcomes	PRIMARY 28‐Day mortality or survival to hospital discharge SECONDARY Shock reversal Improvement in APACHE II score Safety
Notes	Study location: India
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated randomization scheme
Allocation concealment (selection bias)	Low risk	Randomization list kept confidential by the local pharmacist
Blinding (performance bias and detection bias) All outcomes	Low risk	Participants: yes Care‐givers: yes Data collectors: yes Outcome assessors: yes Data analysts: yes
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Lost to follow‐up: unknown
Selective reporting (reporting bias)	Unclear risk	No access to study protocol
Other bias	Unclear risk	No data to exclude selection bias