Valoor 2009

Methods	Randomized controlled trial on 2 parallel groups 1 centre
Participants	Children (n = 38; 2 months to 12 years of age) with septic shock unresponsive to fluid therapy alone
Interventions	Hydrocortisone (intravenous dose of 5 mg/kg/d in 4 divided doses followed by half the dose for a total duration of 7 days) Placebo (normal saline)
Outcomes	PRIMARY Time to shock reversal SECONDARY Vasopressor doses Mortality (unclear time point) Safety
Notes	Study location: India
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No explicit information in the manuscript
Allocation concealment (selection bias)	Unclear risk	No explicit information in the manuscript
Blinding (performance bias and detection bias) All outcomes	High risk	Open label
Incomplete outcome data (attrition bias) All outcomes	Low risk	Lost to follow‐up: none
Selective reporting (reporting bias)	Unclear risk	No information
Other bias	Unclear risk	No information