Yildiz 2002

Methods	Randomized controlled trial 1 centre
Participants	Adults (n = 40) with sepsis (n = 14), severe sepsis (n = 17) and septic shock (n = 9)
Interventions	Prednisolone (2 intravenous boluses: 5 mg at 06:00 and 2.5 mg at 18:00 for 10 days) Placebo
Outcomes	PRIMARY 28‐Day mortality SECONDARY Hospital mortality Safety
Notes	Study location: Turkey
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated randomization scheme
Allocation concealment (selection bias)	Low risk	Randomization list kept confidential by the pharmacist
Blinding (performance bias and detection bias) All outcomes	Low risk	Participants: yes Care‐givers: yes Data collectors: yes Outcome assessors: yes Data analysts: yes
Incomplete outcome data (attrition bias) All outcomes	Low risk	Lost to follow‐up: none
Selective reporting (reporting bias)	Unclear risk	No access to protocol
Other bias	Unclear risk	No data to exclude selection bias