2. Characteristics of studies that contributed data to meta‐analyses (NMES + exercise versus exercise alone).
Study | Setting | Lower limb stimulation | Clinical stability | Dose | Frequency (Hz) | Exercise intervention received by control group |
Abdellaoui 2011 | Intensive care unit | Bilateral quadriceps and hamstrings | Acute exacerbation | 1 hour per day, 5 days per week for 6 weeks at maximum tolerated current | 35 | Both groups received education (once per week) and daily active‐passive mobilisation (control group also received sham stimulation). |
Akar 2017 | Intensive care unit | Bilateral quadriceps | Respiratory failure | 5 days per week (total of 20 sessions) at maximum tolerated current | 50 | Both groups received active exercise, which comprised active joint range of motion exercise for upper and lower limbs. Participants who could not manage active exercise received active‐assisted or passive range of motion exercise. |
Akinlabi 2013 | Home | Bilateral quadriceps and hamstrings | Stable | 2 days per week for 8 weeks (total of 16 sessions) | 10‐50 | Low‐intensity symptom‐limited exercise |
Dang 2011 | Outpatient | Bilateral quadriceps | Stable | 36 min, 3 sessions per week for 12 weeks (total of 36 sessions) at maximum tolerated current | 8‐45 | Usual respiratory rehabilitation (no other details given) |
Kucio 2016 | Inpatient rehabilitation | Bilateral quadriceps and calf | Stable | 36 min, presumably 6 supervised sessions per week for 3 weeks, intensity not specified | 35 | Both groups received breathing exercises, treadmill walking and resistance exercise. |
Tardif 2015 | Home | Bilateral quadriceps | Stable | Presumably 30 min per day, 5 days per week, presumably for 8 weeks at maximum tolerated current | 35 | Both groups received pulmonary rehabilitation. |
Tasdemir 2015 | Outpatient | Bilateral quadriceps | Stable | 20 min, 2 days per week for 10 weeks at maximum tolerated current | 50 | Both groups received pulmonary rehabilitation (control group also received sham stimulation). |
Vivodtzev 2006 | Inpatient rehabilitation | Bilateral quadriceps | Stable, but shortly following acute illness | > 30 min per session, 4 times per week, for 4 weeks at maximum tolerated current | 5‐35 | Both groups received active limb exercises. The strongest participants also performed walking on a treadmill together with 5‐10 min of resistance arm exercises. They also completed health education sessions 1 day per week. |
Zanotti 2003 | Respiratory high dependency unit for inpatient rehabilitation | Bilateral quadriceps and gluteals | Stable, but shortly following acute illness | Up to 30 min per session, 2 times per day, 5 days per week for 4 weeks presumably at maximum tolerated current | 8‐35 | Both groups received rehabilitation that comprised active limb exercises. |
min: minute; NMES: neuromuscular electrostimulation.