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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Chem Rev. 2017 Oct 9;117(20):12764–12850. doi: 10.1021/acs.chemrev.7b00094

Figure 15.

Figure 15.

Control over nanoscale hydrogel mechanics. (A) Decreasing the self-assembly temperature results in collagen fibril bundling and increased fiber diameter (a), which contributes to increased local fiber stiffness (b). Scale bars: μm. Reprinted with permission from ref 720. Copyright 2015 Nature Publishing Group. (B) AuNRs are mixed with collagen to form nanocomposite hydrogels (a–c). The incorporation of AuNRs results in increased nanoscale hydrogel stiffness without impacting the bulk mechanical properties (d). Scale bars: 500 nm for (c, d). Reprinted with permission from ref 721. Copyright 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.