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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Chem Rev. 2017 Oct 9;117(20):12764–12850. doi: 10.1021/acs.chemrev.7b00094

Figure 23.

Figure 23.

Hydrogels with different degradation mechanisms. (A) An enzymatically degradable PEG-based hydrogel. Vinyl sulfone-modified multiarm PEG macromers are functionalized with cell adhesion peptides and then cross-linked with bis-cysteine MMP-sensitive peptides to form enzyme-degradable hydrogels. Reprinted with permission from ref 838. Copyright 2003 Nature Publishing Group. (B) Molecular structure of a hydrolytically degradable triblock copolymer, i.e., PCLA-PEG-PCLA. Reprinted with permission from ref 839. Copyright 2011 Elsevier, Ltd. All rights reserved. (C) A photodegradable PEG-based hydrogel. Such a photodegradable hydrogel system has been used for engineering softening hydrogels. Reprinted with permission from ref 459. Copyright 2009 American Association for the Advancement of Science.