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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Chem Rev. 2017 Oct 9;117(20):12764–12850. doi: 10.1021/acs.chemrev.7b00094

Figure 28.

Figure 28.

Cardiac regeneration using cell aggregate-laden hydrogel vehicles. (A) Schematic of hydrogel injection at different locations for repairing myocardial infarction (MI) in a mouse disease model. (B) Overview of the bioinspired process for fabricating murine ESC aggregate-laden alginate-chitosan micromatrix (ACM) vehicles together with live/dead staining images. Scale bar: 100 μm. (C) Gross images of a normal heart and MI hearts administered five different treatments (ACM-A, cell aggregates with ACM encapsulation; Bare-A, bare predifferentiated aggregate). Arrows indicate granulomas generated in single-cell (Single)- and Bare-A-treated mice. Scale bar: 3 mm. (D) Survival of the mouse disease model at 4 weeks; the ACM-A group exhibited significantly higher survival than all the other groups. (E) Ejection fraction results; the ACM-A treatment significantly enhanced heart function after MI. Reprinted with permission from ref 1032. Copyright 2016 Nature Publishing Group.