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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Chem Rev. 2017 Oct 9;117(20):12764–12850. doi: 10.1021/acs.chemrev.7b00094

Figure 3.

Figure 3.

Schematic representation of cell–ECM interactions. Cells are surrounded by abundant ECM, which provides diverse biochemical cues (e.g., cell adhesion ligands and growth factor immobilization) and biophysical cues (e.g., structural features, mechanical stiffness, and degradation) for guiding cell behaviors.