Comparison 2. Organisational interventions versus usual care.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Mean systolic blood pressure	16	17490	Mean Difference (IV, Random, 95% CI)	‐1.58 [‐4.66, 1.51]
2.2 Mean diastolic blood pressure	14	17178	Mean Difference (IV, Random, 95% CI)	‐0.91 [‐2.75, 0.93]
2.3 Blood pressure target achievement	13	23631	Odds Ratio (M‐H, Random, 95% CI)	0.70 [0.53, 0.92]
2.4 Mean total cholesterol	7	11955	Mean Difference (IV, Random, 95% CI)	‐0.00 [‐0.04, 0.03]
2.5 Total cholesterol target achievement	6	12539	Odds Ratio (M‐H, Random, 95% CI)	0.78 [0.53, 1.17]
2.6 Mean low density lipoprotein	5	1154	Mean Difference (IV, Random, 95% CI)	‐0.19 [‐0.30, ‐0.09]
2.7 Low density lipoprotein target achievement	5	1790	Odds Ratio (M‐H, Random, 95% CI)	0.73 [0.47, 1.13]
2.8 Mean high density lipoprotein	4	522	Mean Difference (IV, Random, 95% CI)	‐0.02 [‐0.09, 0.04]
2.9 High density lipoprotein target achievement	1	36	Odds Ratio (M‐H, Random, 95% CI)	0.79 [0.20, 3.07]
2.10 Mean triglycerides	3	485	Mean Difference (IV, Random, 95% CI)	‐0.08 [‐0.21, 0.04]
2.11 Triglyceride target achievement	1	36	Odds Ratio (M‐H, Random, 95% CI)	4.00 [0.85, 18.84]
2.12 Mean HbA1C	4	554	Mean Difference (IV, Random, 95% CI)	‐0.20 [‐0.98, 0.59]
2.13 HbA1C target achievement	3	553	Odds Ratio (M‐H, Random, 95% CI)	0.25 [0.02, 3.33]
2.14 Mean BMI	5	1089	Mean Difference (IV, Random, 95% CI)	‐0.47 [‐1.24, 0.30]
2.15 BMI target achievement	2	234	Odds Ratio (M‐H, Random, 95% CI)	0.58 [0.31, 1.08]
2.16 Mean Framingham cardiovascular risk score	1	36	Mean Difference (IV, Random, 95% CI)	‐6.50 [‐10.22, ‐2.78]
2.17 Proportion of participants with secondary stroke or TIA	4	791	Odds Ratio (M‐H, Random, 95% CI)	0.66 [0.23, 1.86]
2.18 Number of secondary strokes	4	789	Odds Ratio (M‐H, Random, 95% CI)	1.00 [0.54, 1.87]
2.19 Number of secondary TIAs	1	102	Odds Ratio (M‐H, Random, 95% CI)	3.80 [1.57, 9.24]
2.20 Number of secondary TIA or stroke	1	291	Odds Ratio (M‐H, Random, 95% CI)	0.26 [0.08, 0.85]
2.21 Proportion of participants with secondary cardiovascular events	1	324	Odds Ratio (M‐H, Random, 95% CI)	1.48 [0.79, 2.77]
2.22 Number of secondary cardiovascular events	2	381	Odds Ratio (M‐H, Random, 95% CI)	0.73 [0.25, 2.15]
2.23 Number of myocardial infarctions	1	314	Odds Ratio (M‐H, Random, 95% CI)	1.00 [0.14, 7.19]
2.24 Number of vascular deaths	2	605	Odds Ratio (M‐H, Random, 95% CI)	0.38 [0.15, 0.97]