Brandberg 2008.

Methods	Prospective series
Participants	90 of 98 consecutive women with a hereditary risk of BC who underwent BRRM with reconstruction during October 1997 to December 2005 following counseling about the impact of BRRM
Interventions	BRRM plus reconstruction
Outcomes	QoL
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Free of selection bias?	Low risk	A consecutive sample of a clearly defined population was chosen. “Consecutive women who had BRRM including breast reconstruction between October 1997 and December 2005 were eligible.”
Free of performance bias?	Low risk	Exposure was confirmed in an objective way. All women underwent BRRM at 1 institution (the Karolinka University Hospital) and participated in the same patient consultation program.
Free of detection bias?	High risk	The Sexual Activity Questionnaire (SAQ) had no formal validation or reliability testing on the Swedish translation. 24 of 98 (25%) had BRRSO, known to affect sexuality prior to BRRM.
Free of attrition bias?	High risk	65 of the 90 responded to questionnaires 1 year post‐BRRM, “…making the group that could be analyzed over time small and provides limited power to determine statistically significant differences.”