Frost 2000.

Methods	Case series
Participants	Family history/risk ‐ all had a family history of BC 35% high risk ‐ had a pedigree consistent with a single‐gene autosomal dominant predisposition to BC 65% moderate risk
Interventions	BRRM = 609
Outcomes	QoL
Notes	Duplicate subjects of Hartmann 1999
Risk of bias
Bias	Authors' judgement	Support for judgement
Free of selection bias?	Low risk	All 609 living women who had BRRM at the Mayo Clinic from 1960‐1993 were invited to participate
Free of performance bias?	Low risk	Chart review identified women who had BRRM at the institution, who were then invited to participate
Free of detection bias?	High risk	There is possible recall bias from collecting all psychological data postoperatively.
Free of attrition bias?	Low risk	572 of the 609 (94%) women sent the questionnaire responded