Frost 2005.

Methods	Retrospective case series
Participants	Family history/risk ‐ had a personal and a family history of BC
Interventions	CRRM ‐ 583 women who had CRRM between 1960 to1993 at a single institution
Outcomes	QoL Physical morbidity
Notes	Follow‐up report Frost 2011 Same participants as McDonnell 2001, which reports on BC incidence Same participants as Boughey 2010, which reports on survival and incidence
Risk of bias
Bias	Authors' judgement	Support for judgement
Free of selection bias?	Low risk	Women identified through Mayo Clinic Surgical Index who had CRRM
Free of performance bias?	Low risk	Used medical records
Free of detection bias?	High risk	There were no pre‐CRRM assessments of psychosocial factors for comparison and there is possible recall bias from collecting all psychosocial data postoperatively.
Free of attrition bias?	Low risk	Sent questionnaire to those known to be alive at time of study; 94% of women answered