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. 2018 Apr 5;2018(4):CD002748. doi: 10.1002/14651858.CD002748.pub4

Metcalfe 2005.

Methods Retrospective case series
Participants Family history/risk ‐ 13 were BRCA1/2 mutation carriers, 33 had strong family history (1 first degree relative or 2 second degree relatives with BC plus diagnosis < 51, ovarian cancer or male BC) and 14 had limited family history
Interventions BRRM = 60 women with no history of BC who had BRRM between 1991‐2000 in Ontario, Canada and returned ≥ 1 of 5 questionnaires sent to them
Outcomes QoL
Notes Same participants as Metcalfe 2004b; 75 women were sent the questionnaires
Risk of bias
Bias Authors' judgement Support for judgement
Free of selection bias? High risk Physicians for 20 of 122 potential participants did not give permission to contact their patients.
Free of performance bias? Low risk Hospital procedure & diagnosis codes for RRM used, then medical charts to confirm
Free of detection bias? Low risk Used indices and questionnaires developed and used for other studies and referenced – QoL Index, Brief System Inventory, Body Image After Breast Cancer, Impact of Event Scale, Social Support Questionnaire
Free of attrition bias? High risk 15 of 75 participants did not return questionnaires