Franceschetti 1990.

Methods	Randomised, controlled parallel trial, single centre trial. 2 treatment arms, one no treatment arm No details available in text of randomisation or blinding methods employed Treatment period: unclear Follow up: >6months to <12 months
Participants	Mean age 55 years, 34 men and 29 women undergoing supratentorial craniotomy for neoplasms 128 patients entered trial Group A: 65 participants had pre‐operative seizures and were treated with AEDs (excluded from this review) Group B: 63 participants had no seizures prior to operation and were not taking any AEDs
Interventions	3 treatment arms for Group B randomised participants: PB, PHT and no treatment Group 1: PB (4 mg/kg daily for 5 days), followed by 2 mg/kg daily Group 2: PHT (10 mg/kg daily for 5 days), followed by 5 mg/kg daily Group 3: no treatment
Outcomes	Primary outcomes: efficacy (number of seizures (early and late seizures), adverse effects
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No details in text
Allocation concealment (selection bias)	Unclear risk	No details in text
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No details in text
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Attrition unreported, 24 participants with missing data for late seizure outcome
Selective reporting (reporting bias)	Unclear risk	No trial protocol available
Other bias	Low risk	No other bias detected