Comparison 2.

Diarrhoea secondary outcomes

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Stool frequency, measured as number of depositions per day, on day 3 after starting treatment	3	954	Mean Difference (IV, Random, 95% CI)	‐1.33 [‐2.28, ‐0.38]
2 Stool output, measured in g or mL/kg per day	3	634	Mean Difference (IV, Random, 95% CI)	‐11.37 [‐21.94, ‐0.79]
3 Need for hospitalization	2	885	Risk Ratio (M‐H, Random, 95% CI)	0.93 [0.75, 1.15]
4 Need for intravenous access for rehydration	1	81	Risk Ratio (M‐H, Random, 95% CI)	0.77 [0.54, 1.11]
5 Constipation	2	128	Risk Ratio (M‐H, Random, 95% CI)	4.71 [0.56, 39.19]