Madkour 1993

Methods	Randomized controlled trial Length of follow‐up: until recovery from diarrhoea
Participants	Number: 90 enrolled children Inclusion criteria: inpatients; well‐nourished male children aged 3 to 24 months with watery diarrhoea < 5 days duration, with dehydration of any severity Exclusion criteria: prolonged diarrhoea, malnutrition, major illnesses Breastfeeding: not specified
Interventions	Intervention group: diosmectite. Dosage 1.5 g, 4 times daily for 3 days Control group: placebo
Outcomes	Duration of diarrhoea (from enrolment to last liquid stool) Frequency of diarrhoea Duration of vomiting Feeding pattern
Notes	Location: Egypt Setting: urban Cause of diarrhoea: rotavirus 16%. Other aetiologies not specified. Source of funding: WHO and industry
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Block randomization by Diarrheal Disease Control Programme of the WHO
Allocation concealment (selection bias)	Low risk	Numerically coded envelopes
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Use of placebo
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Use of placebo
Incomplete outcome data (attrition bias) All outcomes	Low risk	No losses to follow‐up
Selective reporting (reporting bias)	Unclear risk	Insufficient information to permit judgement. No protocol registered.
Other bias	Low risk	No other biases detected.