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. 2018 Apr 25;2018(4):CD011526. doi: 10.1002/14651858.CD011526.pub2
Methods Quasi‐randomized controlled trial
Length of follow‐up: not stated
Participants Number: 117 enrolled children
Inclusion criteria: outpatients; well‐nourished children aged 24 to 60 months with watery diarrhoea < 2 days duration; mild‐to‐moderate dehydration
Exclusion criteria: bloody diarrhoea, chronic illness, previous medications
Breastfeeding: not specified
Interventions Intervention group: diosmectite. Dosage 1.5 g thrice a day for 5 days
Control group: no medication
Outcomes Duration of diarrhoea (until normal stool consistency)
Complications: severe dehydration, severe dysentery, respiratory infection, and anaemia
Notes Location: India
Setting: urban
Cause of diarrhoea: not specified
Source of funding: not specified
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) High risk Not truly random; participants selected by serial number.
Allocation concealment (selection bias) High risk Not concealed
Blinding of participants and personnel (performance bias) All outcomes High risk Not blinded
Blinding of outcome assessment (detection bias) All outcomes High risk Not blinded
Incomplete outcome data (attrition bias) All outcomes Low risk Intention‐to‐treat analysis. 8 children (7%) were lost to follow‐up and were included in the analysis.
Selective reporting (reporting bias) Unclear risk Insufficient information to permit judgement. No protocol registered.
Other bias Low risk No other biases detected.