Vivatvakin 1992

Methods	Randomized controlled trial Length of follow‐up: 5 days
Participants	Number: 62 enrolled children Inclusion criteria: inpatients; infants/children aged 1 to 24 months with acute secretory diarrhoea < 3 days duration, with 3 watery stools per day Exclusion criteria: severe dehydration, third‐degree malnutrition, other medications, chronic illnesses Breastfeeding: included
Interventions	Intervention group: diosmectite. Dosage 1.5 g, every 12 hrs for infants < 3 kg; every 8 hrs for infants 4 to 10 kg; every 6 hrs for children 11 to 15 kg, for a maximum of 5 days Control: no medication
Outcomes	Duration of diarrhoea (from first intervention dose until last liquid stool) Number of stools Change in weight Oral liquid intake
Notes	Location: Thailand Setting: urban Cause of diarrhoea: rotavirus in 3% of children in intervention group, 19% in control group. Stool cultures were reported positive for Salmonella and Aeromonas spp. in 7% and 9% of children in the control and study group, respectively, but numbers of each bacterial aetiology per group were not stated. Source of funding: industry
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Stated as randomized, but no method of randomization described. Selection bias is suspected as groups were different in the aetiology of diarrhoea.
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	High risk	Not blinded
Blinding of outcome assessment (detection bias) All outcomes	High risk	Not blinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	No children were lost to follow‐up
Selective reporting (reporting bias)	Unclear risk	Insufficient information to permit judgement. No protocol registered.
Other bias	Low risk	No other biases were detected.