Gilbert 1991

Methods	Randomized controlled trial Length of follow‐up: not stated
Participants	Number: 56 enrolled children Inclusion criteria: inpatients; children aged 2 to 24 months with moderate‐to‐severe acute diarrhoea Exclusion criteria: malnutrition Breastfeeding: not specified
Interventions	Intervention group: diosmectite. Dosage 1.5 g twice a day for infants younger than 12 months. Double the dose for older children Control: placebo Another control group received loperamide 0.11 mg/kg every 8 hours.
Outcomes	Duration of diarrhoea (time to normalization of stools) Stool frequency on day 5
Notes	Location: France Setting: urban Cause of diarrhoea: rotavirus 18%, Staphylococcus aureus 3%, Escherichia coli 3%, Campylobacter spp. 3%, Candida spp. 1% Source of funding: not stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Stated as randomized but no method described.
Allocation concealment (selection bias)	Unclear risk	No method described.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Use of placebo; probably adequate blinding
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Low risk	Per‐protocol analysis. 4 children (7%) excluded and not analysed.
Selective reporting (reporting bias)	Unclear risk	Insufficient information to permit judgement. No protocol registered.
Other bias	Low risk	No other biases detected.