Guarino 2001

Methods	Quasi‐randomized controlled trial Length of follow‐up: not stated
Participants	Number: 804 enrolled children Inclusion criteria: outpatients; well‐nourished children aged 3 to 60 months with acute diarrhoea of mild‐to‐moderate severity < 2 days duration, with 3 watery stools per day Exclusion criteria: malnutrition, chronic diseases, previous medications Breastfeeding: not specified
Interventions	Intervention group: diosmectite. Dosage 1.5 g twice a day for infants younger than 12 months. Double the dose for older children Control: no medication
Outcomes	Duration of diarrhoea (from first to the last liquid–loose stool output preceding the return of normal stools) Diarrhoea at day 7 Vomiting Fever Hospitalization rate
Notes	Location: Italy Setting: urban Cause of diarrhoea: rotavirus 4%, not specified bacterial aetiology 1% Source of funding: industry
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Not randomized. Participants selected in sequential one‐to‐one basis.
Allocation concealment (selection bias)	High risk	Not concealed
Blinding of participants and personnel (performance bias) All outcomes	High risk	Not blinded
Blinding of outcome assessment (detection bias) All outcomes	High risk	Not blinded
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Selective reporting (reporting bias)	Unclear risk	Insufficient information to permit judgement. No protocol registered.
Other bias	Low risk	No other biases detected.