Lachaux 1986

Methods	Randomized controlled trial Length of follow‐up: not stated
Participants	Number: 36 enrolled infants Inclusion criteria: inpatients; infants aged 2 to 24 months with acute watery diarrhoea < 4 days duration, with mild‐to‐moderate dehydration Exclusion criteria: previous medications, concomitant illness Breastfeeding: not stated
Interventions	Intervention group: diosmectite. Dosage 3 g per day to infants < 1 year, 6 g per day to infants > 1 year. Duration not stated. Control: placebo
Outcomes	Duration of diarrhoea (from first drug administration to last liquid stool before a formed one) Clinical resolution at day 3 and 5 Adverse events
Notes	Location: France Setting: urban Cause of diarrhoea: rotavirus 77% Source of funding: not specified
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Stated as "drawing lots"
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Use of placebo; probably adequate blinding
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Use of placebo; probably adequate blinding
Incomplete outcome data (attrition bias) All outcomes	Low risk	Only 1 loss per group
Selective reporting (reporting bias)	Unclear risk	Insufficient information to permit judgement. No protocol registered.
Other bias	Low risk	No other biases detected.