Comparison 4. Vaginal misoprostol versus PGE2 (alone or with other agents).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Vaginal birth not achieved in 24 hours	4	251	Risk Ratio (M‐H, Fixed, 95% CI)	0.62 [0.36, 1.04]
1.1 Low Dose Misoprostol	2	109	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.44, 1.58]
1.2 Moderate Dose Misoprostol	1	16	Risk Ratio (M‐H, Fixed, 95% CI)	0.5 [0.13, 2.00]
1.3 High Dose Misoprostol	1	126	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.10, 1.14]
2 Mean induction to birth interval	4	165	Mean Difference (IV, Random, 95% CI)	‐1.71 [‐10.05, 6.63]
2.1 Low Dose Misoprostol	3	149	Mean Difference (IV, Random, 95% CI)	‐1.00 [‐9.53, 7.53]
2.2 Moderate Dose Misoprostol	1	16	Mean Difference (IV, Random, 95% CI)	‐27.3 [‐76.57, 21.97]
2.3 High Dose Misoprostol	0	0	Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
4 Analgesia required	4	315	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.69, 1.11]
5 Blood loss > 500 mL	4	326	Risk Ratio (M‐H, Fixed, 95% CI)	2.73 [0.69, 10.78]
6 Need for blood transfusion	1	55	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
7 Surgical evacuation of the uterus	5	380	Risk Ratio (M‐H, Random, 95% CI)	0.52 [0.20, 1.36]
8 Side effects ‐ any	1	80	Risk Ratio (M‐H, Fixed, 95% CI)	1.59 [1.05, 2.40]
9 Nausea	1	126	Risk Ratio (M‐H, Fixed, 95% CI)	0.59 [0.35, 0.99]
10 Vomiting	4	254	Risk Ratio (M‐H, Random, 95% CI)	0.87 [0.31, 2.45]
11 Diarrhoea	3	261	Risk Ratio (M‐H, Fixed, 95% CI)	0.20 [0.06, 0.67]
12 Pyrexia	5	380	Risk Ratio (M‐H, Random, 95% CI)	0.88 [0.24, 3.20]